2bfm | pdb_00002bfm

From Proteopedia
Revision as of 08:28, 23 April 2014 by OCA (talk | contribs)
Jump to navigationJump to search

Template:STRUCTURE 2bfm

LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND TRIMETHOPRIM

Template:ABSTRACT PUBMED 16055151

Function

[PTR1_LEIMA] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).[1]

About this Structure

2bfm is a 4 chain structure with sequence from Leishmania major. Full crystallographic information is available from OCA.

See Also

Reference

  1. Schuttelkopf AW, Hardy LW, Beverley SM, Hunter WN. Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design. J Mol Biol. 2005 Sep 9;352(1):105-16. PMID:16055151 doi:https://dx.doi.org/10.1016/j.jmb.2005.06.076
  1. ↑ Bello AR, Nare B, Freedman D, Hardy L, Beverley SM. PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11442-6. PMID:7972081

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2bfm&oldid=1917452"