2l8i | pdb_00002l8i

A biocompatible backbone modification? - Structure and dynamics of a triazole-linked DNA duplex

spinqualitylabelsall models 2l8i, 11 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2l8i is a 2 chain structure. Full experimental information is available from OCA. Activity: Glucokinase, with EC number 2.7.1.2 Publication Abstract from PubMed Blending in: A triazole-modified DNA duplex is perturbed in structure and dynamics, but this is delocalized over five base pairs. The conformation remains B-DNA and hydrogen bonds between the DNA phosphate oxygen and polymerases can be mimicked by the triazole nitrogen. The results explain the surprising biocompatibility of triazole-linked DNA. Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained.,Dallmann A, El-Sagheer AH, Dehmel L, Mugge C, Griesinger C, Ernsting NP, Brown T Chemistry. 2011 Dec 23;17(52):14714-7. doi: 10.1002/chem.201102979. Epub, 2011 Nov 30. PMID:22131102 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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