2ybx | pdb_00002ybx

Crystal Structure of Human Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha

spinqualitylabelsall models 2ybx, resolution 2.56Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2ybx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. Ligands: PO4 NonStd Res: PHD Activity: Glucokinase, with EC number 2.7.1.2 Resources: FirstGlance, OCA, RCSB, PDBsum Disease [PI42A_HUMAN] Precursor B-cell acute lymphoblastic leukemia. Function [PI42A_HUMAN] Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.

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