4d2a | pdb_00004d2a

The limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle

spinqualitylabelsall models 4d2a, resolution 17.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4d2a is a 11 chain structure with sequence from Equine rhinitis a virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 4d14, 4d15, 4d16, 4ctg Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The Picornaviridae family of small, nonenveloped viruses includes major pathogens of humans and animals. They have positive-sense, single-stranded RNA genomes, and the mechanism(s) by which these genomes are introduced into cells to initiate infection remains poorly understood. The structures of presumed uncoating intermediate particles of several picornaviruses show limited expansion and some increased porosity compared to the mature virions. Here, we present the cryo-electron microscopy structure of native equine rhinitis A virus (ERAV), together with the structure of a massively expanded ERAV particle, each at approximately 17-A resolution. The expanded structure has large pores on the particle 3-fold axes and has lost the RNA genome and the capsid protein VP4. The expanded structure thus illustrates both the limits of structural plasticity in such capsids and a plausible route by which genomic RNA might exit. IMPORTANCE: Picornaviruses are important animal and human pathogens that protect their genomic RNAs within a protective protein capsid. Upon infection, this genomic RNA must be able to leave the capsid to initiate a new round of infection. We describe here the structure of a unique, massively expanded state of equine rhinitis A virus that provides insight into how this exit might occur. Limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis a virus particle.,Bakker SE, Groppelli E, Pearson AR, Stockley PG, Rowlands DJ, Ranson NA J Virol. 2014 Jun;88(11):6093-9. doi: 10.1128/JVI.01979-13. Epub 2014 Mar 19. PMID:24648455 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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