3kip | pdb_00003kip

Crystal structure of type-II 3-dehydroquinase from C. albicans

spinqualitylabelsall models 3kip, resolution 2.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3kip is a 24 chain structure with sequence from Candida albicans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4, TRS Gene: DQD1, DHQ99, CaO19.9823 (Candida albicans) Activity: 3-dehydroquinate dehydratase, with EC number 4.2.1.10 Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The combination of transmission electron microscopy with X-ray diffraction data is usually limited to relatively large particles. Here, the approach is continued one step further by utilizing negative staining, a technique that is of wider applicability than cryo-electron microscopy, to produce models of medium-size proteins suitable for molecular replacement. The technique was used to solve the crystal structure of the dodecameric type II dehydroquinase enzyme from Candida albicans (approximately 190 kDa) and that of the orthologous Streptomyces coelicolor protein. Macromolecular crystal data phased by negative-stained electron-microscopy reconstructions.,Trapani S, Schoehn G, Navaza J, Abergel C Acta Crystallogr D Biol Crystallogr. 2010 May;66(Pt 5):514-21. Epub 2010, Apr 21. PMID:20445226 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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