3s88 | pdb_00003s88

Crystal structure of Sudan Ebolavirus Glycoprotein (strain Gulu) bound to 16F6

spinqualitylabelsall models 3s88, resolution 3.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3s88 is a 4 chain structure with sequence from Mus musculus and Sudan ebolavirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NAG Related: 3csy Gene: GP (Sudan ebolavirus) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Sudan virus (genus Ebolavirus) is lethal, yet no monoclonal antibody is known to neutralize it. We here describe antibody 16F6 that neutralizes Sudan virus and present its structure bound to the trimeric viral glycoprotein. Unexpectedly, the 16F6 epitope overlaps that of KZ52, the only other antibody against the GP(1,2) core to be visualized to date. Furthermore, both antibodies against this crucial epitope bridging GP1-GP2 neutralize at a post-internalization step-probably fusion. A shared structural solution for neutralizing ebolaviruses.,Dias JM, Kuehne AI, Abelson DM, Bale S, Wong AC, Halfmann P, Muhammad MA, Fusco ML, Zak SE, Kang E, Kawaoka Y, Chandran K, Dye JM, Saphire EO Nat Struct Mol Biol. 2011 Nov 20;18(12):1424-7. doi: 10.1038/nsmb.2150. PMID:22101933 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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