3soh | pdb_00003soh

Architecture of the Flagellar Rotor

spinqualitylabelsall models 3soh, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3soh is a 4 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 2hp7, 1lkv Gene: TM_0679 (Thermotoga maritima), fliG, TM_0220 (Thermotoga maritima) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Rotation and switching of the bacterial flagellum depends on a large rotor-mounted protein assembly composed of the proteins FliG, FliM and FliN, with FliG most directly involved in rotation. The crystal structure of a complex between the central domains of FliG and FliM, in conjunction with several biochemical and molecular-genetic experiments, reveals the arrangement of the FliG and FliM proteins in the rotor. A stoichiometric mismatch between FliG (26 subunits) and FliM (34 subunits) is explained in terms of two distinct positions for FliM: one where it binds the FliG central domain and another where it binds the FliG C-terminal domain. This architecture provides a structural framework for addressing the mechanisms of motor rotation and direction switching and for unifying the large body of data on motor performance. Recently proposed alternative models of rotor assembly, based on a subunit contact observed in crystals, are not supported by experiment. Architecture of the flagellar rotor.,Paul K, Gonzalez-Bonet G, Bilwes AM, Crane BR, Blair D EMBO J. 2011 Jun 14;30(14):2962-71. doi: 10.1038/emboj.2011.188. PMID:21673656 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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