3txq | pdb_00003txq

Crystal Structure of phage 44RR small terminase gp16

spinqualitylabelsall models 3txq, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3txq is a 11 chain structure with sequence from Aeromonas phage 44rr2.8t. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3txs Gene: 16, gene 16 (Aeromonas phage 44RR2.8t) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Tailed DNA bacteriophages assemble empty procapsids that are subsequently filled with the viral genome by means of a DNA packaging machine situated at a special fivefold vertex. The packaging machine consists of a "small terminase" and a "large terminase" component. One of the functions of the small terminase is to initiate packaging of the viral genome, whereas the large terminase is responsible for the ATP-powered translocation of DNA. The small terminase subunit has three domains, an N-terminal DNA-binding domain, a central oligomerization domain, and a C-terminal domain for interacting with the large terminase. Here we report structures of the central domain in two different oligomerization states for a small terminase from the T4 family of phages. In addition, we report biochemical studies that establish the function for each of the small terminase domains. On the basis of the structural and biochemical information, we propose a model for DNA packaging initiation. Structure and function of the small terminase component of the DNA packaging machine in T4-like bacteriophages.,Sun S, Gao S, Kondabagil K, Xiang Y, Rossmann MG, Rao VB Proc Natl Acad Sci U S A. 2011 Dec 29. PMID:22207623 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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