4did | pdb_00004did

Crystal structure of Salmonella effector N-terminal domain SopB in complex with Cdc42

spinqualitylabelsall models 4did, resolution 2.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4did is a 2 chain structure with sequence from Homo sapiens and Salmonella enterica subsp. enterica serovar typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GDP, MG Gene: CDC42 (Homo sapiens), sigD, sopB, STM1091 (Salmonella enterica subsp. enterica serovar Typhimurium) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed SopB is a Type III secreted Salmonella effector protein with phosphoinositide phosphatase activity and a GTPase binding domain that interacts with host Cdc42, an essential Rho GTPase that regulates critical events in eukaryotic cytoskeleton organization and membrane trafficking. Structural and biochemical analysis of the SopB GTPase binding domain in complex with Cdc42 shows for the first time that SopB structurally and functionally mimics a host guanine nucleotide dissociation inhibitor (GDI) by contacting key residues in the regulatory switch regions of Cdc42 and slowing Cdc42 nucleotide exchange. Structure of Salmonella Effector Protein SopB N-terminal domain in complex with Host Rho GTPase Cdc42.,Burkinshaw B, Strynadka NC J Biol Chem. 2012 Feb 23. PMID:22362774 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also GTP-binding protein

Proteopedia Page Contributors and Editors (what is this?)

OCA