4a7c | pdb_00004a7c

Crystal structure of PIM1 kinase with ETP46546

spinqualitylabelsall models 4a7c, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4a7c is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ACT, E46, IMD NonStd Res: SEP Related: 2bik, 2xix, 1ywv, 2bzj, 2c3i, 1yxu, 2j2i, 1yxt, 2bzh, 1yxs, 1xqz, 1yi3, 2xiz, 1yxv, 1xr1, 2xiy, 2bil, 1yhs, 1yxx, 1xws, 2xj1, 2bzk, 2xj0, 2xj2, 1yi4, 2bzi Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed PIM kinases have become targets of interest due to their association with biochemical mechanisms affecting survival, proliferation and cytokine production. 1,2,3-Triazolo[4,5-b]pyridines were identified as PIM inhibitors applying a scaffold hopping approach. Initial exploration around this scaffold and X-ray crystallographic data are hereby described. Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors.,Pastor J, Oyarzabal J, Saluste G, Alvarez RM, Rivero V, Ramos F, Cendon E, Blanco-Aparicio C, Ajenjo N, Cebria A, Albarran MI, Cebrian D, Corrionero A, Fominaya J, Montoya G, Mazzorana M Bioorg Med Chem Lett. 2012 Feb 15;22(4):1591-7. Epub 2012 Jan 5. PMID:22266039 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Proto-oncogene serine/threonine-protein kinase

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