3zya | pdb_00003zya

Human p38 MAP Kinase in Complex with 2-amino-phenylamino- dibenzosuberone

spinqualitylabelsall models 3zya, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3zya is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 2A8 Related: 2baj, 1wfc, 3zsi, 1w7h, 1wbo, 1kv2, 1yqj, 1bmk, 1bl7, 1zyj, 1a9u, 1wbt, 2i0h, 3zs5, 2yiw, 2baq, 1wbv, 1zz2, 1di9, 1w83, 1bl6, 1m7q, 3zsh, 1ian, 1oz1, 1wbn, 2bak, 3zsg, 2bal, 1wbs, 1ouy, 1ouk, 2y8o, 1r39, 2yis, 1kv1, 1wbw, 1w82, 2yix, 1r3c, 1ove, 1w84, 1zzl Activity: Mitogen-activated protein kinase, with EC number 2.7.11.24 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Until now, a lack of inhibitors with high potency and selectivity in vivo has hampered investigation of the p38 mitogen-activated protein kinase (MAPK) signaling pathway. We describe the design of skepinone-L, which is, to our knowledge, the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, skepinone-L is a valuable probe for chemical biology research, and it may foster the development of a unique class of kinase inhibitors. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.,Koeberle SC, Romir J, Fischer S, Koeberle A, Schattel V, Albrecht W, Grutter C, Werz O, Rauh D, Stehle T, Laufer SA Nat Chem Biol. 2011 Dec 25. doi: 10.1038/nchembio.761. PMID:22198732 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Mitogen-activated protein kinase

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