4ofv | pdb_00004ofv

Refinement of RAGE-DNA complex in 3S58 without DNA

spinqualitylabelsall models 4ofv, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ofv is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3s58 Gene: AGER, RAGE (HUMAN) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed A recent paper by Sirois et al. in The Journal of Experimental Medicine reports that the receptor for advanced glycation end-products (RAGE) promotes uptake of DNA into endosomes and lowers the immune recognition threshold for the activation of Toll-like receptor 9. Two crystal structures suggested that the DNA phosphate-deoxyribose backbone is recognized by RAGE through well-defined interactions. However, the electron densities for the DNA molecules are weak enough that the presented modeling of DNA is questionable, and models only containing RAGE account for the observed diffraction data just as well as the RAGE-DNA complexes presented by the authors. The specificity of DNA recognition by the RAGE receptor.,Yatime L, Andersen GR J Exp Med. 2014 May 5;211(5):749-50. doi: 10.1084/jem.20132526. Epub 2014 Apr 28. PMID:24778420 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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