Exoenzyme

spinqualitylabelsall models Structure of exoenzyme C3 catalytic domain complex with ADP and NAD (PDB code 2c8c). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Exoenzymes (Exo) are secreted by cells and break large macromolecules outside the cells. The breakdown components can pass through the cell wall. Exo C3 is a Clostridium butulinum toxin which binds NAD, splits it into ADP-ribose and nicotinamide and transfers the ADP-ribose to a protein substrate. Exo S and Exo T are secreted by Pseudomonas aeruginosa and has GTPase-activating activity as well as ADP-ribosyltransferase activity. 3D structures of exoenzyme Updated on 01-July-2014 Exoenzyme C3 1g24 – CbExo residues 8-218 – Clostridium butulinum 1uzi, 1r45, 1r4b, 2c89 – CbExo catalytic domain 1gze, 2c8b, 2c8d, 2c8e, 2c8g – CbExo catalytic domain (mutant) 3bw8 - Exo catalytic domain - Clostridium limosum Exoenzyme C3 complexes 1gzf – CbExo catalytic domain + pyridinium derivative + ADP + NAD 2bov – CbExo + GDP + Ral-A GTPase 2a78 – CbExo catalytic domain + GDP + Ral-A GTPase 2a9k – CbExo catalytic domain+ GDP + Ral-A GTPase + NAD 2c8a – CbExo catalytic domain + nicotinamide 2c8c – CbExo catalytic domain (mutant) + ADP + NAD 2c8f, 2c8h – CbExo catalytic domain (mutant) + NAD Exoenzyme S 1r4t – PaExo GAP domain – Pseudomonas aeruginosa - NMR 1he1 – PaExo GAP domain + Ras-like protein + GDP 1he9 – PaExo GAP domain + Ras-like protein Exoenzyme T 4jmf – PaExo residues 28-77 + chaperone

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky