Choline kinase

<StructureSection load='2ckp' size='340' side='right' caption='Structure of human choline kinase α2 complex with phosphocholine (PDB code 2ckp). ' scene=>

Function

Choline kinase (CK) catalyzes the conversion of choline and ATP to phosphocholine and ADP. CK is part of phosphatidylcholine biosynthesis.

Disease

Overexpression of CK α1 was found in various types of cancer cells. This can aid in promoting cancer cells survival and growth. CK α1 is used as cancer biomarker and anticancer drug target.

3D structures of choline kinase

Updated on 06-July-2014

2i7q – hCK α – human
2cko – hCK α2

Choline kinase complexes

2ckp – hCK α2 + ADP
2ckp – hCK α2 + phosphocholine
3zm9, 4da5, 4br3 – hCK α + inhibitor
3f2r – hCK α + hemicholinium-3
3g15 – hCK α + hemicholinium-3 + ADP
4cg8, 4cg9, 4cga – hCK α1 + bispyridinium derivative

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky