2mp2 | pdb_00002mp2

Solution structure of SUMO dimer in complex with SIM2-3 from RNF4

spinqualitylabelsall models 2mp2, 10 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2mp2 is a 3 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages with SUMO chains on linked substrates and catalyses their ubiquitination, which targets substrates for proteasomal degradation. Here we use a segmental labelling approach combined with solution nuclear magnetic resonance (NMR) spectroscopy and biochemical characterization to reveal how RNF4 manipulates the conformation of the SUMO chain, thereby facilitating optimal delivery of the distal SUMO domain for ubiquitin transfer. Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4.,Xu Y, Plechanovova A, Simpson P, Marchant J, Leidecker O, Kraatz S, Hay RT, Matthews SJ Nat Commun. 2014 Jun 27;5:4217. doi: 10.1038/ncomms5217. PMID:24969970 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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