Nitrile hydratase

<StructureSection load='3a8o' size='340' side='right' caption='Structure of nitrile hydratase α,β subunits complex with Fe+3 ion and trimethylacetonitrile (PDB code 3a8o). ' scene=>

Function

Nitrile hydratase (NH) catalyze the hydration of nitriles to amides. NH contains Fe or Co in its active site. NH consists of two subunits: α and β and exists as dimer or tetramer with one metal ion bound per dimer.

Relevance

Nitrile hydratase is used industrially in the production of acrylamide and nicotinamide.

3D structures of nitrile hydratase

Updated on 13-August-2014

1ahj, 2cyz, 2cz0, 2cz1 – ReNH α,β subunits + Fe – Rhodococcus erythropolis
2czf, 3a8l – ReNH α (mutant),β subunits + Fe

Nitrile hydratase complex

2ahj – ReNH α,β subunits + Fe + NO2
2cz6, 2d0q – ReNH α,β subunits + Fe + cyclohexyl isocyanate
2cz7, 2zpb – ReNH α,β subunits + Fe + NO
2qdy – ReNH α,β subunits + Fe + isobutyronitrile
2zpe, 2zpg, 2zph, 2zpi – ReNH α,β subunits + Fe + tert-butyl isocyanate
2zpf – ReNH α,β subunits + Fe + tert-butyl isocyanate + NO
3a8o – ReNH α,β subunits + Fe + trimethyl acetonitrile
3a8g – ReNH α (mutant),β subunits + Fe + trimethyl acetonitrile + NO
3a8h – ReNH α (mutant),β subunits + Fe + trimethyl acetonitrile
3a8m – ReNH α,β (mutant) subunits + Fe + trimethyl acetonitrile

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Alexander Berchansky, Michal Harel