Geranylgeranyl transferase

<StructureSection load='3dst' size='340' side='right' caption='Structure of rat geranylgeranyl transferase type 2 subunits α (grey) and β (green) complex with geranylgeranyl pyrophosphate, Zn+2 (grey) and Ca+2 (green) ions(PDB code 3dst).' scene=>

Function

Geranylgeranyl transferase type 1 (GGT1) adds a 20-carbon isoprenoid group called geranylgeranyl (GG) to the C-terminal of proteins containg the CAAX motif (Cysteine, Aliphatic, Aliphatic, any amino acid). Geranylgeranyl transferase type 2 (GGT2) adds 2 GG groups to C-terminal cysteine residue of a protein. The addition of the hydrophobic prenyl group causes the proteins to become membrane-associated.

3D structures of eranylgeranyl transferase

Updated on 14-August-2014

Geranylgeranyl transferase type 1

1s64 – rGGT1 α+β subunits + inhibitor - rat
1n4p – rGGT1 α+β subunits + GGPP
1n4s, 1n4r – rGGT1 α+β subunits + GGPP + peptide-GG containing CAAX
1tnb, 1tno, 1tnu, 1tny, 1tnz, 1n4q – rGGT1 α+β subunits + GGPP analog + peptide containing CAAX
3dra – GGT1 α+β subunits + GGPP – Candida albicans

Geranylgeranyl transferase type 2

1dce – rGGT2 α+β subunits – rat
3dss – rGGT2 α+β subunits

Geranylgeranyl transferase type 2 complex

3c72, 3pz1, 3pz3, 4ehm, 4gts, 4gtt, 4gtv – rGGT2 α+β subunits + inhibitor
3hxb, 3hxc, 3hxd, 3hxe, 3hxf – rGGT2 α (mutant) +β subunits + inhibitor
1ltx – rGGT α+β subunits + tetra-alanine + Rab escort protein + farnesyl
3dst – rGGT2 α+β subunits + GGPP
3dsu – rGGT2 α+β subunits + farnesyl-PP
3dsv, 3dsw, 3dsx – rGGT2 α+β subunits + GG
3pz2 – rGGT2 α+β subunits + GGPP + inhibitor

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky