4n14 | pdb_00004n14

Crystal structure of Cdc20 and apcin complex

spinqualitylabelsall models 4n14, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4n14 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: WR7 Related: 4gga, 4ggc, 4ggd Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Cdc20 is an essential cell-cycle regulator required for the completion of mitosis in organisms from yeast to man and contains at its C terminus a WD40 repeat domain that mediates protein-protein interactions. In mitosis, Cdc20 binds to and activates the ubiquitin ligase activity of a large molecular machine called the anaphase-promoting complex/cyclosome (APC/C) and enables the ubiquitination and degradation of securin and cyclin B, thus promoting the onset of anaphase and mitotic exit. APC/C(Cdc20) is temporally and spatially regulated during the somatic and embryonic cell cycle by numerous mechanisms, including the spindle checkpoint and the cytostatic factor (CSF). Therefore, Cdc20 serves as an integrator of multiple intracellular signaling cascades that regulate progression through mitosis. This review summarizes recent progress toward the understanding of the functions of Cdc20, the mechanisms by which it activates APC/C, and its regulation by phosphorylation and by association with its binding proteins. Cdc20: a WD40 activator for a cell cycle degradation machine.,Yu H Mol Cell. 2007 Jul 6;27(1):3-16. PMID:17612486 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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