RmlC

<StructureSection load='2ixc' size='340' side='right' caption='Structure of RmlC complex with dTPD-rhamnose (PDB code 2ixc).' scene=>

RmlC is an enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human.

Relevance

Inhibitors of RmlC can serve as potential antimicrobial drugs.

3D structures of RmlC

Updated on 21-August-2014

1pm7, 1upi – MtRmlC – Mycobacterium tuberculosis
2ixj, 1rtv – PaRmlC – Pseudomonas aeruginosa
1nxm – SsRmlC – Streptococcus suis
1ep0 – MetRmlC – Methanothermobacter thermautotrophicus
1dzr – StRmlC – Salmonella typhimurium

RmlC complexes

2ixc – MtRmlC + dTDP rhamnose
2ixh – PaRmlC + dTDP rhamnose
2ixl – SsRmlC + dTDP rhamnose
2ixk – PaRmlC + dTDP-keto rhamnose
1nyw – SsRmlC + dTDP glucose
1nzc – SsRmlC + dTDP xylose
1epz – MetRmlC + TDP
3ryk – RmlC + TDP + pyrophosphate – Bacillus anthracis
1dzt – StRmlC + acetylthymidine diphosphate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky