4qla | pdb_00004qla

Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori

spinqualitylabelsall models 4qla, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4qla is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 1PE Activity: Microsomal epoxide hydrolase, with EC number 3.3.2.9 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The juvenile hormone (JH) epoxide hydrolase (JHEH) catalyzes the degradation of JH, which regulates the metamorphosis development of insects. Here we report the 2.30 A crystal structure of JHEH from the silkworm Bombyx mori (BmJHEH). The overall structure of BmJHEH is composed of an N-terminal segment followed by a core hydrolase domain, which is interrupted by an all-alpha lid domain. Structural analyses together with molecular simulation reveal insights into the conservation and specificity of the active-site pocket. These findings increase our understanding of the substrate recognition and catalysis of microsomal epoxide hydrolase family and might help the design of JH-derived pesticides. (c) Proteins 2014;. (c) 2014 Wiley Periodicals, Inc. Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori.,Zhou K, Jia N, Hu C, Jiang YL, Yang JP, Chen Y, Li S, Li WF, Zhou CZ Proteins. 2014 Aug 21. doi: 10.1002/prot.24676. PMID:25143157 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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