1dik | pdb_00001dik

PYRUVATE PHOSPHATE DIKINASE

spinqualitylabelsall models 1dik, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1dik is a 1 chain structure with sequence from Clostridium symbiosum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 Related: 2r82 Gene: PPDK (Clostridium symbiosum) Activity: Pyruvate, phosphate dikinase, with EC number 2.7.9.1 Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The crystal structure of pyruvate phosphate dikinase, a histidyl multiphosphotransfer enzyme that synthesizes adenosine triphosphate, reveals a three-domain molecule in which the phosphohistidine domain is flanked by the nucleotide and the phosphoenolpyruvate/pyruvate domains, with the two substrate binding sites approximately 45 angstroms apart. The modes of substrate binding have been deduced by analogy to D-Ala-D-Ala ligase and to pyruvate kinase. Coupling between the two remote active sites is facilitated by two conformational states of the phosphohistidine domain. While the crystal structure represents the state of interaction with the nucleotide, the second state is achieved by swiveling around two flexible peptide linkers. This dramatic conformational transition brings the phosphocarrier residue in close proximity to phosphoenolpyruvate/pyruvate. The swiveling-domain paradigm provides an effective mechanism for communication in complex multidomain/multiactive site proteins. Swiveling-domain mechanism for enzymatic phosphotransfer between remote reaction sites.,Herzberg O, Chen CC, Kapadia G, McGuire M, Carroll LJ, Noh SJ, Dunaway-Mariano D Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2652-7. PMID:8610096 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Pyruvate phosphate dikinase

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OCA, Joel L. Sussman