1k83 | pdb_00001k83

Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin

spinqualitylabelsall models 1k83, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1k83 is a 11 chain structure with sequence from Amanita phalloides and Saccharomyces cerevisiae. The April 2003 RCSB PDB Molecule of the Month feature on RNA Polymerase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2003_4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MN, ZN NonStd Res: CSX, HYP, ILX, TRX Related: 1i50, 2vum, 3cqz Activity: DNA-directed RNA polymerase, with EC number 2.7.7.6 Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism. Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution.,Bushnell DA, Cramer P, Kornberg RD Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1218-22. Epub 2002 Jan 22. PMID:11805306 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also RNA polymerase

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