1oxb | pdb_00001oxb

Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)

spinqualitylabelsall models 1oxb, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1oxb is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 Related: 1qsp, 1oxk Gene: YPD1 (Saccharomyces cerevisiae), SLN1 OR YPD2 OR YIL147C (Saccharomyces cerevisiae) Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed In Saccharomyces cerevisiae, a branched multistep phosphorelay signaling pathway regulates cellular adaptation to hyperosmotic stress. YPD1 functions as a histidine-phosphorylated protein intermediate required for phosphoryl group transfer from a membrane-bound sensor histidine kinase (SLN1) to two distinct response regulator proteins (SSK1 and SKN7). These four proteins are evolutionarily related to the well-characterized "two-component" regulatory proteins from bacteria. Although structural information is available for many two-component signaling proteins, there are very few examples of complexes between interacting phosphorelay partners. Here we report the first crystal structure of a prototypical monomeric histidine-containing phosphotransfer (HPt) protein YPD1 in complex with its upstream phosphodonor, the response regulator domain associated with SLN1. The yeast YPD1/SLN1 complex: insights into molecular recognition in two-component signaling systems.,Xu Q, Porter SW, West AH Structure. 2003 Dec;11(12):1569-81. PMID:14656441 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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