1t7k | pdb_00001t7k

Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea

spinqualitylabelsall models 1t7k, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1t7k is a 2 chain structure with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BH0 Related: 1mui Gene: POL (Human immunodeficiency virus 1) Activity: HIV-1 retropepsin, with EC number 3.4.23.16 Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed A series of novel azacyclic urea HIV protease inhibitors bearing a benzenesulfonamide group at P1' were synthesized utilizing a parallel synthesis method. Structural studies of early analogs bound in the enzyme active site were used to design more potent inhibitors. The effects of substituting the P1' benzenesulfonyl group on antiviral activity and protein binding are described. Synthesis and antiviral activity of P1' arylsulfonamide azacyclic urea HIV protease inhibitors.,Huang PP, Randolph JT, Klein LL, Vasavanonda S, Dekhtyar T, Stoll VS, Kempf DJ Bioorg Med Chem Lett. 2004 Aug 2;14(15):4075-8. PMID:15225729 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Virus protease

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