1tx7 | pdb_00001tx7

Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)

spinqualitylabelsall models 1tx7, resolution 1.75Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1tx7 is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 4CM, CA Activity: Trypsin, with EC number 3.4.21.4 Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed p-amidinophenylmethylphosphinic acid (AMPA) was designed, synthesized and crystallized in complex with trypsin to study interactions with the oxyanion hole at the S1 site. In comparison to benzamidine, AMPA shows improved activity, which the crystal structure demonstrates to result from hydrogen bonds between the negatively charged phosphinic acid group and the catalytic residues at the oxyanion hole. An oxyanion-hole selective serine protease inhibitor in complex with trypsin.,Cui J, Marankan F, Fu W, Crich D, Mesecar A, Johnson ME Bioorg Med Chem. 2002 Jan;10(1):41-6. PMID:11738605 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Trypsin

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