1qmc | pdb_00001qmc

C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES

spinqualitylabelsall models 1qmc, 42 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1qmc is a 2 chain structure with sequence from Human immunodeficiency virus 1. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 1a5v, 1a5w, 1a5x, 1aub, 1b9d, 1b9f, 1bhl, 1bi4, 1bis, 1biu, 1bl3, 1wja, 1wjb, 1wjc, 1wjd, 1wje, 1wjf, 2itg Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase has been refined using nuclear magnetic resonance spectroscopy. The protein is a dimer in solution and shows a well-defined dimer interface. The folding topology of the monomer consists of a five-stranded beta-barrel that resembles that of Src homology 3 domains. Compared with our previously reported structure, the structure is now defined far better. The final 42 structures display a back-bone root mean square deviation versus the average of 0.46 A. Correlation of the structure with recent mutagenesis studies suggests two possible models for DNA binding. Proteins 1999;36:556-564. Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase.,Eijkelenboom AP, Sprangers R, Hard K, Puras Lutzke RA, Plasterk RH, Boelens R, Kaptein R Proteins. 1999 Sep 1;36(4):556-64. PMID:10450096 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also HIV integrase Retroviral Integrase

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