2fuf | pdb_00002fuf

Crystal structure of the SV40 large T antigen origin-binding domain

spinqualitylabelsall models 2fuf, resolution 1.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2fuf is a 1 chain structure with sequence from Simian virus 40. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: FLC NonStd Res: MSE Related: 1tbd Gene: SV40 A GENE (Simian virus 40) Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The origins of replication of DNA tumor viruses have a highly conserved feature, namely, multiple binding sites for their respective initiator proteins arranged as inverted repeats. In the 1.45-angstroms crystal structure of the simian virus 40 large T-antigen (T-ag) origin-binding domain (obd) reported herein, T-ag obd monomers form a left-handed spiral with an inner channel of 30 angstroms having six monomers per turn. The inner surface of the spiral is positively charged and includes residues known to bind DNA. Residues implicated in hexamerization of full-length T-ag are located at the interface between adjacent T-ag obd monomers. These data provide a high-resolution model of the hexamer of origin-binding domains observed in electron microscopy studies and allow the obd's to be oriented relative to the hexamer of T-ag helicase domains to which they are connected. Crystal structure of the simian virus 40 large T-antigen origin-binding domain.,Meinke G, Bullock PA, Bohm A J Virol. 2006 May;80(9):4304-12. PMID:16611889 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Large T Antigen

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