2duv | pdb_00002duv

Structure of CDK2 with a 3-hydroxychromones

spinqualitylabelsall models 2duv, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2duv is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 371 Activity: Cyclin-dependent kinase, with EC number 2.7.11.22 Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells. 3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.,Lee J, Park T, Jeong S, Kim KH, Hong C Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:17178224 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Cell division protein kinase 2

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