2ot8 | pdb_00002ot8

Karyopherin Beta2/Transportin-hnRNPM NLS Complex

spinqualitylabelsall models 2ot8, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2ot8 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 1qbk, 2h4m Gene: TNPO1, KPNB2, MIP1, TRN (Homo sapiens), HNRPM (Homo sapiens) Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Kapbeta2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M. Structure-based design of a pathway-specific nuclear import inhibitor.,Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:17435768 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Importin Nucleoprotein

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