1gen | pdb_00001gen
| |||||||||||||
| 1gen, resolution 2.15Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | ZN, CA, CL and NA | ||||||||||||
| Gene: | HUMAN GELATINASE A (Homo sapiens) | ||||||||||||
| Activity: | Gelatinase A, with EC number 3.4.24.24 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
C-TERMINAL DOMAIN OF GELATINASE A
Overview
The crystal structure of the haemopexin-like C-terminal domain of gelatinase A reveals that it is a four-bladed beta-propeller protein. The four blades are arranged around a channel-like opening in which Ca2+ and a Na-Cl+ ion pair are bound.
Disease
Known diseases associated with this structure: Osteolysis, idiopathic, Saudi type OMIM:[120360], Winchester syndrome OMIM:[120360]
About this Structure
1GEN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the haemopexin-like C-terminal domain of gelatinase A., Libson AM, Gittis AG, Collier IE, Marmer BL, Goldberg GI, Lattman EE, Nat Struct Biol. 1995 Nov;2(11):938-42. PMID:7583664
Page seeded by OCA on Thu Mar 20 11:22:06 2008
