1gpf | pdb_00001gpf
CHITINASE B FROM SERRATIA MARCESCENS IN COMPLEX WITH INHIBITOR PSAMMAPLIN
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| 1gpf, resolution 1.85Å | |||||||||||||
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| Sites: | AC1 | ||||||||||||
| Ligands: | SO4 | ||||||||||||
| Activity: | Chitinase, with EC number 3.2.1.14 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
Several brominated tyrosine derived compounds, psammaplins A (1), K (2) and L (3) as well as bisaprasin (4) were isolated from the Fijian marine sponge Aplysinella rhax during a bioassay guided isolation protocol. Their structures were determined using NMR and MS techniques. Psammaplin A was found to moderately inhibit chitinase B from Serratia marcescens, the mode of inhibition being non-competitive. Crystallographic studies suggest that a disordered psammaplin A molecule is bound near the active site. Interestingly, psammaplin A was found to be a potent antifungal agent.
About this Structure
1GPF is a Single protein structure of sequence from Serratia marcescens. Full crystallographic information is available from OCA.
Reference
Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax., Tabudravu JN, Eijsink VG, Gooday GW, Jaspars M, Komander D, Legg M, Synstad B, van Aalten DM, Bioorg Med Chem. 2002 Apr;10(4):1123-8. PMID:11836123
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