1sus | pdb_00001sus

Crystal structure of alfalfa feruoyl coenzyme A 3-O-methyltransferase

spinqualitylabelsall models 1sus, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1sus is a 4 chain structure with sequence from Medicago sativa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, SAH, SPF Related: 1sui Gene: CCOMT (Medicago sativa) Activity: Caffeoyl-CoA O-methyltransferase, with EC number 2.1.1.104 Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Caffeoyl coenzyme A 3-O-methyltransferases (CCoAOMTs) are S-adenosyl-l-methionine-dependent O-methyltransferases (OMTs) involved in lignin biosynthesis. Plant CCoAOMTs belong to a distinct family of OMTs, more closely related to the mammalian catechol OMTs than to other plant OMTs. The crystal structure of alfalfa (Medicago sativa) CCoAOMT in complex with the reaction products S-adenosine-l-homocysteine and feruloyl/sinapoyl CoAs presented here belong to a structurally and mechanistically distinct family of plant small molecule OMTs. These structures provide a new understanding of the substrate preferences and the catalytic mechanism accompanying CCoAOMT-mediated O-methylation of CoA-linked phenylpropanoid substrates. Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase.,Ferrer JL, Zubieta C, Dixon RA, Noel JP Plant Physiol. 2005 Mar;137(3):1009-17. Epub 2005 Feb 25. PMID:15734921 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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