1sfo | pdb_00001sfo

RNA POLYMERASE II STRAND SEPARATED ELONGATION COMPLEX

spinqualitylabelsall models 1sfo, resolution 3.61Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1sfo is a 12 chain structure with sequence from Saccharomyces cerevisiae. This structure supersedes the now removed PDB entry 1r9r. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MG, ZN Related: 1r9s, 1r9t Activity: DNA-directed RNA polymerase, with EC number 2.7.7.6 Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The structure of an RNA polymerase II-transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape. Structural basis of transcription: separation of RNA from DNA by RNA polymerase II.,Westover KD, Bushnell DA, Kornberg RD Science. 2004 Feb 13;303(5660):1014-6. PMID:14963331 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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