1xpn | pdb_00001xpn

NMR structure of P. aeruginosa protein PA1324: Northeast Structural Genomics Consortium target PaP1

spinqualitylabelsall models 1xpn, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1xpn is a 1 chain structure with sequence from Pseudomonas aeruginosa pao1. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: PA1324 (Pseudomonas aeruginosa PAO1) Resources: FirstGlance, OCA, RCSB, PDBsum, TOPSAN Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Pseudomonas aeruginosa is the prototypical biofilm-forming gram-negative opportunistic human pathogen. P. aeruginosa is causatively associated with nosocomial infections and with cystic fibrosis. Antibiotic resistance in some strains adds to the inherent difficulties that result from biofilm formation when treating P. aeruginosa infections. Transcriptional profiling studies suggest widespread changes in the proteome during quorum sensing and biofilm development. Many of the proteins found to be upregulated during these processes are poorly characterized from a functional standpoint. Here, we report the solution NMR structure of PA1324, a protein of unknown function identified in these studies, and provide a putative biological functional assignment based on the observed prealbumin-like fold and FAST-NMR ligand screening studies. PA1324 is postulated to be involved in the binding and transport of sugars or polysaccharides associated with the peptidoglycan matrix during biofilm formation. Structure and function of Pseudomonas aeruginosa protein PA1324 (21-170).,Mercier KA, Cort JR, Kennedy MA, Lockert EE, Ni S, Shortridge MD, Powers R Protein Sci. 2009 Mar;18(3):606-18. PMID:19241370 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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