1ugv | pdb_00001ugv

Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)

spinqualitylabelsall models 1ugv, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1ugv is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: Kazusa cDNA hg04539 (Homo sapiens) Resources: FirstGlance, OCA, RCSB, PDBsum, TOPSAN Disease [RHG26_HUMAN] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient. Function [RHG26_HUMAN] GTPase-activating protein for RHOA and CDC42. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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