2oau | pdb_00002oau

Mechanosensitive Channel of Small Conductance (MscS)

spinqualitylabelsall models 2oau, resolution 3.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2oau is a 7 chain structure with sequence from Escherichia coli. This structure supersedes the now removed PDB entry 1mxm. The November 2008 RCSB PDB Molecule of the Month feature on Mechanosensitive Channels by David Goodsell is 10.2210/rcsb_pdb/mom_2008_11. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: mscS (Escherichia coli) Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The mechanosensitive channel of small conductance (MscS) responds both to stretching of the cell membrane and to membrane depolarization. The crystal structure at 3.9 angstroms resolution demonstrates that Escherichia coli MscS folds as a membrane-spanning heptamer with a large cytoplasmic region. Each subunit contains three transmembrane helices (TM1, -2, and -3), with the TM3 helices lining the pore, while TM1 and TM2, with membrane-embedded arginines, are likely candidates for the tension and voltage sensors. The transmembrane pore, apparently captured in an open state, connects to a large chamber, formed within the cytoplasmic region, that connects to the cytoplasm through openings that may function as molecular filters. Although MscS is likely to be structurally distinct from other ion channels, similarities in gating mechanisms suggest common structural elements. Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel.,Bass RB, Strop P, Barclay M, Rees DC Science. 2002 Nov 22;298(5598):1582-7. PMID:12446901 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ion channels Mechanosensitive channels: opening and closing

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