2nmv | pdb_00002nmv

Damage detection by the UvrABC pathway: Crystal structure of UvrB bound to fluorescein-adducted DNA

spinqualitylabelsall models 2nmv, resolution 2.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2nmv is a 3 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ADP, FLU, NML Related: 2d7d Gene: uvrB (Bacillus subtilis) Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed UvrB is the damage recognition element of the highly conserved UvrABC pathway that functions in the removal of bulky DNA adducts. Pivotal to this is the formation of a damage detection complex that relies on the ability of UvrB to locate and sequester diverse lesions. Whilst structures of UvrB bound to DNA have recently been reported, none address the issue of lesion recognition. Here, we describe the crystal structure of UvrB bound to a pentanucleotide containing a single fluorescein-adducted thymine that reveals a unique mechanism for damage detection entirely dependent on the exclusion of lesions larger than an undamaged nucleotide. Damage detection by the UvrABC pathway: crystal structure of UvrB bound to fluorescein-adducted DNA.,Waters TR, Eryilmaz J, Geddes S, Barrett TE FEBS Lett. 2006 Nov 27;580(27):6423-7. Epub 2006 Nov 3. PMID:17097086 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also UvrABC

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