2wql | pdb_00002wql

CRYSTAL STRUCTURE OF THE MAJOR CARROT ALLERGEN DAU C 1

spinqualitylabelsall models 2wql, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2wql is a 4 chain structure with sequence from Daucus carota. This structure supersedes the now removed PDB entry 2vjg. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, P4C, PEG Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Dau c 1 is a major allergen of carrot (Daucus carota) which displays IgE cross-reactivity with the homologous major birch-pollen allergen Bet v 1. The crystal structure of Dau c 1 has been determined to a resolution of 2.7 A, revealing tight dimers. The structure of Dau c 1 is similar to those of the major allergens from celery, Api g 1, and birch pollen, Bet v 1. Electron density has been observed in the hydrophobic cavity of each monomer and has been modelled with polyethylene glycol oligomers of varying length. Comparison of the surface topology and physicochemical properties of Dau c 1 and Bet v 1 revealed that they may have some, but not all, epitopes in common. This is in agreement with the observation that the majority of carrot-allergic patients have Bet v 1 cross-reactive IgE antibodies, whereas others have Dau c 1-specific IgE antibodies which do not recognize Bet v 1. Structure of the major carrot allergen Dau c 1.,Markovic-Housley Z, Basle A, Padavattan S, Maderegger B, Schirmer T, Hoffmann-Sommergruber K Acta Crystallogr D Biol Crystallogr. 2009 Nov;65(Pt 11):1206-12. Epub 2009, Oct 22. PMID:19923716 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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