2x04 | pdb_00002x04

CRYSTAL STRUCTURE OF THE PABC-TNRC6C COMPLEX

spinqualitylabelsall models 2x04, resolution 1.49Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2x04 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 Related: 1jgn, 1jh4, 1g9l, 2dkl, 1cvj Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed GW182-family proteins are essential for microRNA-mediated translational repression and deadenylation in animal cells. Here we show that a conserved motif in the human GW182 paralog TNRC6C interacts with the C-terminal domain of polyadenylate binding protein 1 (PABC) and present the crystal structure of the complex. Mutations at the complex interface impair mRNA deadenylation in mammalian cell extracts, suggesting that the GW182-PABC interaction contributes to microRNA-mediated gene silencing. Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation.,Jinek M, Fabian MR, Coyle SM, Sonenberg N, Doudna JA Nat Struct Mol Biol. 2010 Feb;17(2):238-40. Epub 2010 Jan 24. PMID:20098421 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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