4wee | pdb_00004wee

High-resolution structure of Synaptotagmin 1 C2A

spinqualitylabelsall models 4wee, resolution 0.89Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4wee is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NA, SO4 Related: 1rsy Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed C2 domains are regulatory sequence motifs that occur widely in nature. Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+ regulation of exocytosis, contains two C2 domains, the first of which acts as a Ca2+ sensor. We now describe the three-dimensional structure of this C2 domain at 1.9 A resolution in both the Ca(2+)-bound and Ca(2+)-free forms. The C2 polypeptide forms an eight-stranded beta sandwich constructed around a conserved four-stranded motif designated as a C2 key. Ca2+ binds in a cup-shaped depression between two polypeptide loops located at the N- and C-termini of the C2-key motif. Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.,Sutton RB, Davletov BA, Berghuis AM, Sudhof TC, Sprang SR Cell. 1995 Mar 24;80(6):929-38. PMID:7697723 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA