4cwd | pdb_00004cwd

CRYSTAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE,2-OXOGLUTARATE IN COMPLEX WITH 449, A NOVEL SUBSTRATE

spinqualitylabelsall models 4cwd, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4cwd is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 449, NI, OGA, PEG, ZN Activity: Gamma-butyrobetaine dioxygenase, with EC number 1.14.11.1 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed gamma-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the final hydroxylation step in the biosynthesis of carnitine. BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products with two or three stereogenic centers. Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids.,Rydzik AM, Leung IK, Kochan GT, McDonough MA, Claridge TD, Schofield CJ Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10925-7. doi: 10.1002/anie.201406125., Epub 2014 Aug 27. PMID:25164544 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA