2wbk | pdb_00002wbk

Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis

spinqualitylabelsall models 2wbk, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2wbk is a 2 chain structure with sequence from Bactn. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BR, CL, EDO, M2F Related: 2vqt, 2vot, 2vl4, 2vqu, 2vo5, 2je8, 2vr4, 2vjx, 2vmf Activity: Beta-mannosidase, with EC number 3.2.1.25 Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The Michaelis complex of the beta-mannosidase Man2A shows distortion to a (1)S(5) conformation adding to the growing body of evidence supporting catalysis through a boat conformation. Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis.,Offen WA, Zechel DL, Withers SG, Gilbert HJ, Davies GJ Chem Commun (Camb). 2009 May 14;(18):2484-6. Epub 2009 Apr 6. PMID:19532864 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Mannosidase

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