4u32 | pdb_00004u32

Human mesotrypsin complexed with HAI-2 Kunitz domain 1

spinqualitylabelsall models 4u32, resolution 1.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4u32 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, NAG Related: 4u30 Activity: Trypsin, with EC number 3.4.21.4 Resources: FirstGlance, OCA, RCSB, PDBsum Disease [SPIT2_HUMAN] Congenital sodium diarrhea. The disease is caused by mutations affecting the gene represented in this entry. Function [SPIT2_HUMAN] Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. [TRY3_HUMAN] Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.

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