2l0r | pdb_00002l0r

Conformational Dynamics of the Anthrax Lethal Factor Catalytic Center

spinqualitylabelsall models 2l0r, 31 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2l0r is a 1 chain structure with sequence from Bacillus anthracis. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: BXA0172, GBAA_pXO1_0172, lef, pXO1-107 (Bacillus anthracis) Activity: Anthrax lethal factor endopeptidase, with EC number 3.4.24.83 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Anthrax lethal factor (LF) is a zinc-metalloprotease that together with the protective antigen constitutes anthrax lethal toxin, which is the most prominent virulence factor of the anthrax disease. The solution nuclear magnetic resonance and in silico conformational dynamics of the 105 C-terminal residues of the LF catalytic core domain in its apo form are described here. The polypeptide adopts a compact structure even in the absence of the Zn(2+) cofactor, while the 40 N-terminal residues comprising the metal ligands and residues that participate in substrate and inhibitor recognition exhibit more flexibility than the C-terminal region. Conformational dynamics of the anthrax lethal factor catalytic center.,Dalkas GA, Chasapis CT, Gkazonis PV, Bentrop D, Spyroulias GA Biochemistry. 2010 Dec 28;49(51):10767-9. Epub 2010 Dec 3. PMID:21121613 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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