2xzn | pdb_00002xzn

CRYSTAL STRUCTURE OF THE EUKARYOTIC 40S RIBOSOMAL SUBUNIT IN COMPLEX WITH INITIATION FACTOR 1. THIS FILE CONTAINS THE 40S SUBUNIT AND INITIATION FACTOR FOR MOLECULE 2

spinqualitylabelsall models 2xzn, resolution 3.93Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2xzn is a 35 chain structure with sequence from Tetrahymena thermophila. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MG, ZN NonStd Res: UNK Related: 2xzm Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Eukaryotic ribosomes are substantially larger and more complex than their bacterial counterparts. Although their core function is conserved, bacterial and eukaryotic protein synthesis differ considerably at the level of initiation. The eukaryotic small ribosomal subunit (40S) plays a central role in this process; it binds initiation factors that facilitate scanning of messenger RNAs and initiation of protein synthesis. We have determined the crystal structure of the Tetrahymena thermophila 40S ribosomal subunit in complex with eukaryotic initiation factor 1 (eIF1) at 3.9 A resolution. The structure reveals the fold of the entire 18S rRNA and of all ribosomal proteins of the 40S subunit and defines the interactions with the eIF1. It provides insights into the eukaryotic-specific aspects of protein synthesis including the function of eIF1, and signaling and regulation mediated by ribosomal proteins RACK1 and rpS6e. Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1.,Rabl J, Leibundgut M, Ataide SF, Haag A, Ban N Science. 2010 Dec 23. PMID:21205638 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ribosome 3D structures

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