2xkv | pdb_00002xkv

Atomic Model of the SRP-FtsY Early Conformation

spinqualitylabelsall models 2xkv, resolution 13.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2xkv is a 4 chain structure with sequence from [1], "bacillus_coli"_migula_1895 "bacillus coli" migula 1895 and Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 2j28, 2j7p, 1jpj, 1ng1, 2cnw, 2c03, 1dul, 2ng1, 1ls1, 1o87, 1ry1, 1jpn, 2j45, 2j46, 1rj9, 1ffh, 1hq1, 2ffh, 2c04, 2iyl, 1okk, 2iy3, 3ng1 Activity: Signal-recognition-particle GTPase, with EC number 3.6.5.4 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed We report the 'early' conformation of the Escherichia coli signal recognition particle (SRP) and its receptor FtsY bound to the translating ribosome, as determined by cryo-EM. FtsY binds to the tetraloop of the SRP RNA, whereas the NG domains of the SRP protein and FtsY interact weakly in this conformation. Our results suggest that optimal positioning of the SRP RNA tetraloop and the Ffh NG domain leads to FtsY recruitment. Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor.,Estrozi LF, Boehringer D, Shan SO, Ban N, Schaffitzel C Nat Struct Mol Biol. 2011 Jan;18(1):88-90. Epub 2010 Dec 12. PMID:21151118 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Signal recognition particle protein Signal recognition particle receptor

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