4u4i | pdb_00004u4i

Megavirus chilensis superoxide dismutase

spinqualitylabelsall models 4u4i, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4u4i is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: MSE Activity: Superoxide dismutase, with EC number 1.15.1.1 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Megavirus chilensis, a close relative of the Mimivirus giant virus, is able to replicate in Acanthamoeba castellanii. The first step of viral infection involves the internalization of the virions in host vacuoles. It has been experimentally demonstrated that Mimivirus particles contain many proteins capable of resisting oxidative stress, as encountered in the phagocytic process. These proteins are conserved in Megavirus, which has an additional gene (Mg277) encoding a putative superoxide dismutase. The Mg277 ORF product was overexpressed in Escherichia coli, purified and crystallized. A SAD data set was collected to 2.24 A resolution at the selenium peak wavelength on the BM30 beamline at the ESRF from a single crystal of selenomethionine-substituted recombinant superoxide dismutase protein. Preliminary crystallographic analysis of the Megavirus superoxide dismutase.,Lartigue A, Philippe N, Jeudy S, Abergel C Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1557-9., doi: 10.1107/S174430911204657X. Epub 2012 Nov 28. PMID:23192047 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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