3wlu | pdb_00003wlu

Crystal Structure of human galectin-9 NCRD with Selenolactose

spinqualitylabelsall models 3wlu, resolution 1.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3wlu is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: LSE Related: 2eak Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Seleno-lactoses have been successfully synthesized as candidates for mimicking carbohydrate ligands for human galectin-9 N-terminal carbohydrate recognition domain (NCRD). Selenium was introduced into the mono- or di-saccharides using p-methylselenobenzoic anhydride (Tol2Se) as a novel selenating reagent. The TolSe-substituted monosaccharides were converted into selenoglycosyl donors or acceptors, which were reacted with coupling partners to afford seleno-lactoses. The seleno-lactoses were converted to the target compounds. The structure of human galectin-9 NCRD co-crystallized with 6-MeSe-lactose was determined with single/multi-wavelength anomalous dispersion (SAD/MAD) phasing and was similar to that of the co-crystal with natural lactose. Expanded potential of seleno-carbohydrates as a molecular tool for X-ray structural determination of a carbohydrate-protein complex with single/multi-wavelength anomalous dispersion phasing.,Suzuki T, Makyio H, Ando H, Komura N, Menjo M, Yamada Y, Imamura A, Ishida H, Wakatsuki S, Kato R, Kiso M Bioorg Med Chem. 2014 Apr 1;22(7):2090-101. doi: 10.1016/j.bmc.2014.02.023. Epub , 2014 Feb 25. PMID:24631362 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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