4txc | pdb_00004txc

Crystal Structure of DAPK1 kinase domain in complex with a small molecule inhibitor

spinqualitylabelsall models 4txc, resolution 1.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4txc is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 38G, EDO Related: 2yak, 4pf4 Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed A novel imidazo-pyramidazine inhibitor of DAPK1 that undergoes class-specific interactions and extends into the substrate recognition site has been identified. This inhibitor is a good starting point for the development of selective and potent inhibitors of DAPK1, with potential use against stroke and ischemia. Identification and Characterization of a Small-Molecule Inhibitor of Death-Associated Protein Kinase 1.,Wilbek TS, Skovgaard T, Sorrell FJ, Knapp S, Berthelsen J, Stromgaard K Chembiochem. 2014 Nov 7. doi: 10.1002/cbic.201402512. PMID:25382253 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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