3eb8 | pdb_00003eb8

VirA

spinqualitylabelsall models 3eb8, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3eb8 is a 2 chain structure with sequence from Shigella flexneri. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: virA, CP0181, pWR501_0191 (Shigella flexneri) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed VirA, an essential virulence factor in Shigella disease pathogenesis, is involved in the uptake, motility, and cell-to-cell spread of Shigella organisms within the human host. These functions have been attributed to a VirA protease activity and a mechanism of microtubule destruction via tubulin degradation [Yoshida, S., et al. (2006) Science 314, 985-989]. We report functional and crystallographic data indicating a novel VirA structure that lacks these activities but highlights the homology to the EspG virulence factor of pathogenic Escherichia coli. Structural and functional studies indicate that Shigella VirA is not a protease and does not directly destabilize microtubules.,Germane KL, Ohi R, Goldberg MB, Spiller BW Biochemistry. 2008 Sep 30;47(39):10241-3. Epub 2008 Sep 3. PMID:18763811 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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